Mild cognitive impairment associated with higher serum 25-hydroxyvitamin D levels in a middle aged population living at a moderately high latitude in New Zealand
Notice bibliographique
Résumé
Objective: The association between serum 25-hydroxyvitamin D (s25OHD) concentrations and cognitive function has been investigated in only a few studies of middle aged adults (40-60 years); with inconsistent results found. The main objective of this Canterbury-based study was to examine the association between s25OHD levels and mild cognitive impairment (MCI) in participants in their early fifties, while adjusting for a number of confounders. The secondary objective was to assess if this association would differ when stratified by gender.\nDesign: Cross-sectional study participants, 366 adults aged 49-53 years living within the Canterbury District Health Board region from the Canterbury Health, Aging and Life Course study, were divided into two cognitive function groups: MCI and normal cognitive function (NCF). A score of <26 on the Montreal Cognitive Assessment test was defined as MCI and NCF was defined as a score ≥26 out of 30. Logistic regression was used to investigate the relationship between the cognitive function groups (outcome variable) and two s25OHD groups: insufficient s25OHD (≤50 nanomoles per litre (nmol/L)) and sufficient s25OHD (>50 nmol/L). Age, gender, education, ethnicity, annual household income, body mass index, depression, season of blood draw, alcohol intake, current smoking status, serum intact parathyroid hormone, serum creatinine, general health, vitamin D food intake, calcium food intake, vitamin D supplement use and chronic diseases were considered as potential confounders.\nResults: In the univariate and multivariate logistic regression with cognitive function as the binary outcome variable (MCI (n=89) and NCF (n=277)) and vitamin D as a continuous predictor variable, the results did not reach statistical significance (crude odds ratio (OR) 1 (0.99, 1.01) p=0.306, adjusted OR 0.99 (0.98, 1.00) p=0.084). However, an inverse association between s25OHD levels and cognitive function were observed in the univariate and multivariate logistic regression with vitamin D as a categorical variable. Compared to those with MCI, participants with NCF belonged more often to the insufficient s25OHD group (≤50 nmol/L, n=124) than the sufficient s25OHD group (>50 nmol/L, (n=242)) (crude OR 0.52 (0.30, 0.89) p=0.020, adjusted OR 0.44 (0.24, 0.79) p=0.008). In the analyses stratified by gender, the effect observed was similar, however, the association reached statistical significance only for female participants (adjusted OR 0.43 (0.18, 0.94) p=0.041) and not for male participants (adjusted OR 0.48 (0.18, 1.19) p=0.127). Further adjusted for vitamin D supplement use and season, did not change the effect size, however was just statistically significant, for female participants (adjusted OR 0.43 (0.17, 0.99) p=0.053).\nConclusions: Those with MCI belonged more often to the s25OHD group >50 nmol/L than the s25OHD group ≤50 nmol/L in a middle aged community-dwelling cohort, mostly for women, and appeared to be due to vitamin D supplement use. However, causality cannot be concluded due to the cross-sectional design of this study.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».