Results of a Delphi Panel to Address Management of Gastrointestinal Side Effects Observed with Use of Delayed-release Dimethyl Fumarate (P3.242)
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Notice bibliographique
Résumé
OBJECTIVE: To gain insight into gastrointestinal (GI) events associated with delayed-release dimethyl fumarate (DMF) from clinicians who treat patients with relapsing-remitting multiple sclerosis (RRMS), and to obtain consensus on effective management strategies and appropriate expectations for patients with GI events. BACKGROUND: Delayed-release DMF (240 mg twice daily) is approved for treatment of relapsing forms of MS (USA, Australia) or relapsing-remitting MS (Canada, EU). In clinical trials, events associated with GI tolerability (nausea, vomiting, abdominal pain, diarrhea) were more common in patients treated with delayed-release DMF compared with placebo-treated patients. The Delphi method (a consensus-building technique) was initiated in the US and Canada to obtain information about managing these side effects in a real-world setting. DESIGN/METHODS: A steering committee designed and conducted surveys of clinicians in the US and Canada whose MS patients receive treatment with delayed-release DMF. Two rounds of questionnaires were developed that include questions relating to clinician experience with treatment-associated GI events. Results from the first questionnaire were used to develop the second questionnaire and were provided along with the second questionnaire in an effort to obtain consensus on the management of each specific GI event. RESULTS: Sixty-four respondents completed the first round questionnaire. Most (63/64) indicated that 蠅1 of their patients had experienced GI side effects (typically <20[percnt] of patients). Most strategies attempted to manage the GI side effects, including food-based strategies, prescription medications, and/or nonprescription medications were reported as effective some of the time. The most frequently used strategies were included in the second round questionnaire to obtain consensus (蠅70[percnt] agreement) regarding their potential effectiveness. The final results of the Delphi process will be presented. CONCLUSIONS: Strategies identified by clinicians to manage GI events associated with delayed-release DMF will be important in clinical practice to improve tolerability and compliance. Study Supported by: Biogen Idec Inc.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle