Ability of the Quinones Arising from the UV Irradiation of Anthracene to Induce 7-Ethoxyresorufin-O-Deethylase Activity in a Trout Liver Cell Line
Bibliographic record
Abstract
Quinone derivatives of the polycyclic aromatic hydrocarbon, anthracene, were investigated for their ability to induce 7-ethoxyresorufin-O-deethylase (EROD) activity in a cell line from rainbow trout liver, RTL-W1. Of the 11 anthracene quinones tested, five were capable of inducing EROD activity. From most to the least potent, the order of induction potency, based on EC50 values, was 2,6-dihydroxyanthraquinone = 1,2,4trihydroxyanthraquinone < 1,2-dihydroxyanthraquinone = 1,3-dihydroxyanthraquinone = 2-hydroxyanthraquinone. The 1,2,10-trihydroxylated anthracene also induced EROD activity whereas anthraquinone did not, indicating that the quinone structure alone was not adequate for EROD induction to occur. The current results show that UV irradiation of an AhR-inactive PAH, such as anthracene, can yield derivatives that are AhR active and induce EROD activity in fish cells and presumably in fish. Thus, responses mediated by the AhR and/or P4501A should be considered in the environmental risk assessment of UV/PAH interactions.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".