Functional variants of the cysteinyl leukotriene 1 and cysteinyl leukotriene 2 receptors are associated with atopic asthma
Bibliographic record
Abstract
The atopy phenotype is reported to be a risk factor for asthma. Among the many loci that contribute to a genetic predisposition to asthma, the cysteinyl leukotriene receptor 1 (cysLT1) and 2 (cysLT2) genes have been important subjects of study because they are functionally and pharmacologically implicated in the atopy phenotype affecting many asthma subjects. In some populations we have found that the G300S variant of the cysLT1 receptor is associated with atopy. In an earlier association study, the M201V variant of the CysLT2 was implicated in atopic asthma. In this study we identify the statistical association of both the variants with the atopy phenotype. We propose a two hit hypothesis of atopy inheritance that involves the cysLT1 and cyLT2 variants. In vitro analyses are beginning to provide evidence that cysLT1 and cysLT2 interaction within the cell is possible and may represent a mechanism for the etiology of atopy in asthmatic populations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".