Treatment of Ulcerative Necrobiosis Lipoidica with Topical Calcineurin Inhibitor: Case Report and Literature Review
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Background: Ulcerative necrobiosis lipoidica (UNL) is an uncommon disease, which is frequently recalcitrant to available therapies. It is characterized by well-defined, ulcerated plaques with indurated borders and atrophic centers. Multiple therapeutic options have been described, with variable success rates. Objective: To report the efficacy of using topical tacrolimus in treating UNL. Method: Topical tacrolimus was used in the treatment of two patients with UNL. Result: Topical tacrolimus is effective in treating UNL. Conclusion: Topical tacrolimus is a reasonably effective choice in treating UNL. Contexte: La nécrobiose lipoïdique ulcérée (NLU) est une maladie rare, qui est souvent réfractaire au traitement. Elle se caractérise par des placards ulcérés et bien définis, des bords indurés et des centres atrophiques. Différentes formes de traitement ont été utilisées et se sont soldées par des taux variables de réussite. Objectif: L'étude visait à faire état de l'efficacité du tacrolimus topique dans le traitement de la NLU. Méthode: Nous avons fait usage de tacrolimus topique dans le traitement de la NLU chez deux patients. Résultat: Le tacrolimus topique s'est montré efficace dans le traitement de la NLU. Conclusion: Le tacrolimus topique est un moyen relativement efficace de traitement de la NLU.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.005 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it