Bibliographic record
Abstract
The thymus provides a unique three-dimensional hematopoietic environment that is essential for the development of T (thymus-derived) lymphocytes. T-cell progenitors do not arise in the thymus itself, but migrate to the thymus from central hematopoietic organs such as the liver and bone marrow during fetal and adult life, respectively (1–3) . Despite the fact that prethymic T lineage-committed progenitors have been identified (e.g., in fetal blood) (4) ,adult thymus-colonizing pro-T cells have remained elusive. Moreover, the molecular and cellular basis underlying thymus homing has not been resolved. Intrathymic stages of T-cell development have been studied in great detail both at the cellular and the molecular levels (reviewed in refs. 5–7 ). The intrathymic developmental sequence can be ordered into three major stages: Growth factor-driven proliferation and protection from apoptosis of rare pro-T cells ( growth factor expansion phase ; reviewed in refs. 8 and 9 ). Rearrangement of β, γ, and δ T-cell antigen receptor (TCR) genes, followed by thymocyte selection for further development based on the expression of productive TCR β-chains. This process, termed β-selection , depends on the assembly of the pre-TCR complex (reviewed in ref. 10 ). The β-selected thymocytes undergo massive proliferation and become CD4 + CD8 + , still immature, thymocytes. Following TCR α-chain rearrangements, the pre-TCR is replaced by the αβTCR complex at the CD4 + CD8 + stage. Cells that succeed to assemble a complete αβ-TCR can be selected based on TCR-MHC (major histocompatibility complex) interactions ( αβ-selection ). Thymocytes undergo further differentiation as CD4 + CD8 − (helper-type) or CD4 − CD8 + (cytotoxic-type) singlepositive cells before they populate as MHC-restricted ( positive selection ) and self-tolerant ( negative selection ) antigen-reactive T cells the circulation and the peripheral lymphoid organs (reviewed in ref.5).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".