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Distinguishing Between Restoration and Enhancement in Neuropharmacology

2010· article· en· W114981308 on OpenAlexaff
Peter B. Reiner

Bibliographic record

VenueThe AMA Journal of Ethic · 2010
Typearticle
Languageen
FieldNeuroscience
TopicNeuroethics, Human Enhancement, Biomedical Innovations
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsNeuropharmacologyNeurosciencePsychology

Abstract

fetched live from OpenAlex

A patient comes to your office telling you that she finds herself having a bit of difficulty maintaining concentration. At 51 years old, she has a demanding job in the financial industry, is never far from either a computer or her PDA, and carries two cell phones, one for friends and family and the other for work. You give her a thorough examination (noting that she checks her PDA twice during the exam), which reveals that she is healthy and without any neurological or psychiatric dysfunction. She mentions that one of her coworkers, who is also continually bombarded by information and multitasks ferociously, went to his physician and received a drug which seemed to help him. He seems happier now and his life is less out of control. She tells you that she generally would prefer not to take drugs, but the combined demands of her job, her family, and modern life are such that she needs some kind of help, and she needs it now.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.009
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0030.001
Science and technology studies0.0010.006
Scholarly communication0.0030.005
Open science0.0010.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.084
GPT teacher head0.375
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2010
Admission routes1
Has abstractyes

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