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Effect of human serum on cancer cell growth

2007· article· en· W11722820 on OpenAlexaff
Amin Esfahani, Balachandran Bashyam, Cyril W.C. Kendall, Michael C. Archer, David J.A. Jenkins

Bibliographic record

VenueThe FASEB Journal · 2007
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNutrition, Genetics, and Disease
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
Fundersnot available
KeywordsLNCaPCancerEndocrinologyIncubation periodIncubationInternal medicineHormoneTestosterone (patch)MedicineGlucagonPhysiologyEx vivoCancer cellBiologyIn vitroOncologyBiochemistry

Abstract

fetched live from OpenAlex

Background: Specific Dietary components have been linked to promotion or inhibition of cancer. We have therefore undertaken a series of studies to develop reliable ex vivo methodology for assessing the effect of diet on cancer development, by incubating serum from subjects, who have participated in dietary intervention studies, with various types of human cancer cell lines. Hypothesis: Serum from a given subject will constantly result in a consistant pattern of in vitro cell growth, different from other individuals providing diet and lifestyle patterns are unchanged. Methods: Blood will be taken from 20 healthy male and postmenopausal female volunteers once a week for a period of three weeks. The sera from subjects will be incubated with MCF‐7, MCF‐10A, and LNCaP cells. After 72 hours of incubation cell viability will be measured with the use of MTS assay. In addition, the effects of glucagon, insulin, E2, DHEA, DHT and testosterone will be tested in all cell lines. Results: The study is currently in progress. The results from both the human study and hormonal analysis will be presented.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.269
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2007
Admission routes1
Has abstractyes

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