Sox9 knock‐down in mice improves locomotor recovery after spinal cord injury by reducing CSPG levels and facilitating reactive sprouting
Bibliographic record
Abstract
We have identified the transcription factor SOX9 as a key regulator of chondroitin sulfate proteoglycan (CSPG) production in the injured spinal cord. CSPGs in the lesion epicenter are produced by reactive astrocytes responding to the injury. CSPGs are also key components of the perineuronal matrix that surround the cell bodies and dendrites of many neurons in the central nervous system. Thus CSPGs may limit plasticity after SCI by inhibiting regeneration of axons through the glial scar or by inhibiting reactive sprouting at deafferented targets distant to the lesion. We have demonstrated reduced CSPG levels and improved locomotor recovery in spinal cord‐injured Sox9 conditional knockout mice. Herein we investigated sparing, long‐range regeneration and reactive sprouting as possible explanations for the improved locomotor outcomes in Sox9 knockout mice after SCI. We herein demonstrate that the improved recovery of locomotor function in Sox9 conditional knockout mice after SCI is due to increased reactive sprouting secondary to reduced CSPG levels distal to the lesion.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".