Effects of dietary protein source and isoflavones on bone quality in Dahl salt‐sensitive and salt‐resistant rats
Bibliographic record
Abstract
13 C molar % excess of plasma and intracellular fatty acids in human skeletal muscle This study tested effects of protein source and soy isoflavones (IF) supplementation on bone mass and microarchitecture in hypertensive rats. Weanling male Dahl salt‐sensitive (DS) and Dahl salt‐resistant rats (DR) were fed one of six experimental diets for 12 wk and given drinking water with 10 g NaCl / L to induce earlier hypertension. Sixty DS and 60 DR rats (10/group) were randomly assigned to one of the following: casein control, casein +100 mg isoflavones/kg diet, casein + 200 mg isoflavones/kg, soy protein isolate (SPI) which was alcohol washed to be devoid of isoflavones SPI + 100 mg isoflavones/kg or SPI + 200 mg isoflavones/kg. At necropsy, a hind limb was stored at −20 o C. Femurs were isolated later. Mortality was high among DS rats supplemented with IF, but surviving DS rats were significantly heavier than DR rats. With dual‐energy X‐ray absorptiometry (DEXA), bone mineral area and bone mineral content were higher in DS rats than in DR. To assess microarchitecture, the distal femur was scanned at 16.5 μ intervals and 100 slices were contoured. Bone volume fraction (BV/TV) was significantly lowered by IF in DS but not in DR rats; this reduction was seen with both casein and SPI. In the DS rats, significant decreases in connectivity density and increases in trabecular separation supported the BV/TV results. Cortical thickness at the femur midshaft was also significantly reduced by IF in DS rats but not in DR. In this study addition of IF to the diet significantly impaired bone quality in DS rats and had little effect in DR rats.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".