Polymeric Gene Delivery: Principles and Applications

Introduction Robert Langer, MIT, Cambridge, MA GENE DELIVERY: CHALLENGES AND OPPORTUNITIES Tissue and Cell Specific Targeting for the Delivery of Genetic Information Randall J. Mrsny, University of Wales, UK Biological Barriers to Gene Transfer Yasufumi Kaneda, Osaka University, Japan Cellular Uptake and Trafficking Sujatha Dokka and Yon Rojanasakul, West Virginia University. Morgantown, WV, USA Pharmacokinetics of Polymer/Plasmid DNA Complex Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida, Kyoto University, Japan CONDENSING POLYMERIC SYSTEMS A. Non-Degradable Polymers Poly(L-Lysine) and Copolymers for Gene Delivery Minhyung Lee and Sung Wan Kim, University of Utah, Salt Lake City, USA Gene Delivery Using Polyethyleneimine and Copolymers Manfred Ogris, Centre of Drug Research, LMU Munich, Germany Chapter 8. Poly(2-(Dimethylamino)Ethyl Methacrylate)-Based Polymers for the Delivery of Genes In Vitro and In Vivo .J. Verbaan, D.J.A. Crommelin, W.E. Hennink, and G. Storm, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands Cationic Dendrimers as Gene Transfection Vectors Lori A. Kubasiak and Donald A. Tomalia, Dendritic Nanotechnologies, Inc., Mt. Pleasant, MI Poly(ethylene glycol)-Conjugated Cationic Dendrimers Joon Sig Choi, Tae-il Kim, and Jong-Sang Park, Seoul National University, Korea Water Soluble Lipopolymers for Gene Delivery Ram I. Mahato, University of Tennessee Health Science Center, Memphis, and Sung Wan Kim, University of Utah, Salt Lake City, USA Cyclodextrin-Containing Polymers for Gene Delivery Suzie Hwang Pun, Insert Therapeutics, Pasadena, CA, and Mark E. Davis, California Institute of Technology, Pasadena, CA, USA B. Biodegradable Polymers Gene Delivery Using Polyimidazoles and Related Polymers Sharon Wong and David Putnam, Cornell University, Ithaca, NY, USA Poly(?-amino ester)s for Gene Delivery David M. Lynn, University of Wisconsin, Madison, WI, and Daniel G. Anderson, Akin Akinc, and Robert Langer, Massachusetts Institute of Technology, Cambridge, MA, USA Cationic Polyesters as Biodegradable Gene Delivery Carriers Yong-beom Lim, Yan Lee, and Jong-Sang Park, Seoul National University, Korea Poly(amidoamine)s for Gene Delivery Paolo Ferruti and Jacopo Franchini, University of Milan, Italy Chapter 17. Cationic Polysaccharides for Gene Delivery Tony Azzam and Abraham J. Domb, The Hebrew University - Hadassah Medical School, Jerusalem, Israel Chitosan Complexes Gerrit Borchard and Maytal Bivas-Benita, Leiden University, The Netherlands NON-CONDENSING POLYMERIC SYSTEMS Pluronic(R) Block Copolymers for Non-Viral Gene Delivery Alexander V. Kabanov and Srikanth Sriadibhatla, University of Nebraska Medical Center, Omaha, NE, and Valery Yu. Alakhov, Supratek Pharma, Inc., Dorval, Quebec, Canada Use of Poly(N-vinyl pyrrolidone) with Noncondensed Plasmid DNA Formulations for Gene Therapy and Vaccines Michael Nicolaou and Mark Newman, Epimmune, Inc., San Diego, CA, Polly Chang, SRI International, Menlo Park, CA, USA Use of HPMA Copolymers for Gene Delivery David Oupicky, Wayne State University, Detroit, MI, USA POLYMERIC NANOSPHERES AND MICROSPHERES A. Polymeric Nanospheres Biodegradable Nanoparticles as Gene Expression Vector Swayam Prabha, Wenxue Ma, and Vinod Labhasetwar, University of Nebraska Medical Center, Omaha, USA Nanoparticles Made of Poly(lactic acid) and Poly(ethylene oxide) as Carriers of Plasmid DNA Noemi Csaba, Celso Perez, Alejandro Sanchez, and Maria Jose Alonso, University of Santiago de Compostela, Spain Poly(alkylcyanoacrylate) Nanoparticles for Nucleic Acid Delivery Elias Fattal and Patrick Couvreur, University of Paris-Sud, France Layer-by-Layer Nanoengineering with Polyelectrolytes for Bioactive Compound Delivery Applications Dinesh B. Shenoy, Alexei A. Antipov, and Gleb B. Sukhorukov, Max-Planck Institute of Colloids and Interfaces, Potsdam/Golm, Germany Ex Vivo and In Vivo Adenovirus-Mediated Gene Delivery intro Refractory Cells via Nanoparticle Hydrogel Formulation Ales Prokop and Gianluca Carlesso, Vanderbilt University, Nashville, TN, and Jeffrey M. Davidson, Department of Veteran Affairs Medical Center, Nashville, TN, USA Protein Nanoparticles for Gene Delivery Goldie Kaul and Mansoor Amiji, Northeastern University, Boston, MA, USA B. Polymeric Microspheres Gene Delivery Using Poly(lactide-co-glycolide) Microspheres Mary Lynne Hedley Zycos, Inc. Lexington, MA, USA Polyanhydride Microspheres for Gene Delivery Yong S Jong and Camilla A Santos, Spherics Inc., Lincoln, RI, and Edith Mathiowitz, Brown University, Providence, RI, USA Microspheres Formulated with Native Hyaluronan for Applications in Gene Therapy Yang H. Yun and Weiliam Chen, State University of New York at Stony Brook, Stony Brook, NY, USA SPECIALIZED DELIVERY SYSTEMS Genetically Engineered Protein-Based Polymers: Potential in Gene Delivery Zaki Mageed and Hamid Ghandehari, University of Maryland, Baltimore, MD, USA Glycopolymer Tools for Studying Targeted Non-Viral Gene Delivery Kevin G. Rice, Je-Seon Kim, and Dijie Liu, University of Iowa, Iowa City, USA Targeted Gene Delivery via the Folate Receptor Shih-Jiuan Chiu and Robert J. Lee, Ohio State University, Columbus, USA Transferrin Receptor-Targeted Gene Delivery Systems Ralf Kircheis, Igeneon Immunotherapy of Cancer, Vienna, Austria, and Ernst Wagner, Pharmaceutical Biology/Biotechnology, Ludwig-Maximilians University, Munich, Germany Gene Delivery to the Lungs Berma M. Kinsey, Charles L. Densmore, and Frank M. Orson, Baylor College of Medicine, Houston, TX, USA Cutaneous Gene Delivery James C. Birchall, Cardiff University, Wales, UK Enhancement of Wound Repair by Sustained Gene Transfer via Hyaluronan Matrices Angela Kim, Daniel M. Checkla, Don Wen, Philip Dehazya, and Weiliam Chen1, Clear Solutions Biotech, Inc., Stony Brook, NY, and 1State University of New York at Stony Brook, NY, USA Gene Delivery from Tissue Engineering Matrices Zain Bengali, Christopher B. Rives, and Lonnie D. Shea, Northwestern University, Evanston, IL, USA Gene Therapy Stents for Instent Restenosis Ilia Fishbein, Itay Perlstein, and Robert Levy, University of Pennsylvania Medical Center and Children's Hospital of Philadelphia, PA USA Gene Delivery Using BioMEMS Krishnendu Roy, University of Texas, Austin, USA

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