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Record W1235570584 · doi:10.1038/ng.467

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

2009· article· en· W1235570584 on OpenAlexafffund
Nicole Soranzo, Tim D. Spector, Massimo Mangino, Brigitte Kuehnel, Augusto Rendon, Alexander Teumer, Christina Willenborg, Benjamin J. Wright, Li Chen, Mingyao Li, Perttu Salo, Benjamin F. Voight, Philippa Burns, Roman A. Laskowski, Yali Xue, Stephan Menzel, David Altshuler, John R. Bradley, Suzannah Bumpstead, Mary-Susan Burnett, Joseph M. Devaney, Angela Doering, Roberto Elosúa, Stephen E. Epstein, Wendy N. Erber, Mario Falchi, Stephen F. Garner, Mohammed J. R. Ghori, Alison H. Goodall, Rhian Gwilliam, Håkon Håkonarson, Alistair S. Hall, Naomi Hammond, Christian Hengstenberg, Thomas Illig, Inke R. Koenig, Christopher W. Knouff, Ruth McPherson, Olle Melander, Vincent Mooser, Matthias Nauck, Markku S. Nieminen, Christopher J. O’Donnell, Leena Peltonen, Simon Potter, Holger Prokisch, Daniel J. Rader, Catherine M. Rice, Robert J. Roberts, Veikko Salomaa, Jennifer Sambrook, Stefan Schreiber, Heribert Schunkert, Stephen M. Schwartz, Jovana Serbanovic‐Canic, Juha Sinisalo, David S. Siscovick, Klaus Stark, Ida Surakka, J. Claiborne Stephens, J. Thompson, Uwe Voelker, Henry Voelzke, Nicholas A. Watkins, George A. Wells, H-Erich Wichmann, David A. van Heel, Chris Tyler‐Smith, Swee Lay Thein, Sekar Kathiresan, Markus Perola, Muredach P. Reilly, Alexandre F.R. Stewart, Jeanette Erdmann, Nilesh J. Samani, Christa Meisinger, Andreas Greinacher, Panos Deloukas, Willem H. Ouwehand, Christian Gieger

Bibliographic record

VenueNature Genetics · 2009
Typearticle
Languageen
FieldImmunology and Microbiology
TopicT-cell and Retrovirus Studies
Canadian institutionsUniversity of Ottawa
FundersNational Heart, Lung, and Blood InstituteCanadian Institutes of Health ResearchNational Center for Research ResourcesWellcome Trust
KeywordsMeta-analysisGeneticsBiologyGenomeComputational biologyMedicineGeneInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.021

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.003
Bibliometrics0.0030.004
Science and technology studies0.0010.001
Scholarly communication0.0020.000
Open science0.0010.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.254
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations22
Published2009
Admission routes2
Has abstractno

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