Prostaglandins do not modulate cardiovascular and renal responses to LPS in conscious lambs
Bibliographic record
Abstract
It is well recognized that core temperature responses to LPS are abolished when endogenously produced prostaglandins are removed. The present study was designed to evaluate the role of prostaglandins in the cardiovascular and renal responses to LPS. Core temperature, mean arterial pressure, heart rate, renal blood flow and various parameters of renal function were measured for 60 min before (C) and for 5 h after I.V. injection of 0.03 μg·kg −1 of the LPS SAE (i.e., EC 100 for core temperature response) (N=10, group I), after pretreatment with indomethacin (N=6, 10 mg·kg −1 , group II, to inhibit prostaglandin production) or after vehicle (N=9, group III). The increase in core temperature after LPS was abolished by pretreatment with indomethacin. In contrast the mean arterial pressure, heart rate, renal blood flow, urinary flow and Na + excretion responses to LPS were not altered by indomethacin pretreatment. Therefore, in young lambs, cardiovascular and renal responses to LPS appear to be independent of endogenously produced prostaglandins.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".