A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera)
Bibliographic record
Abstract
Circadian clocks are central to physiology. In animals, clocks are distributed in cells and tissues throughout the organism. The specific role of these clocks in the tissues within which they reside as well as the way they communicate and interact with each other is unclear. Using immunohistochemistry and laser confocal microscopy I have investigated whether the fat body in the insect Rhodnius prolixus contains an autonomous circadian clock. Fat body was found to express the canonical clock protein PER in a circadian fashion in vivo. However, when fat body was incubated in vitro, PER rapidly became undetectable. A pulse of ecdysteroid, but not brain neuropeptide extract, successfully induced PER expression but not cycling. Therefore, Rhodnius fat body does not seem to possess a local clock. It is inferred that PER cycling in the fat body is driven by the known rhythm of ecdysteroid concentration in the haemolymph.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".