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Record W1270702496

Endogenous hydrogen sulfide and the cardiovascular system-what's the smell all about?

2006· article· en· W1270702496 on OpenAlexaff
Russell J. Pearson, Thomas J. Wilson, Rui Wang

Bibliographic record

VenuePubMed · 2006
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSulfur Compounds in Biology
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsHydrogen sulfideVasodilationNitric oxideEndogenyChemistryMedicinePharmacologyNeuroscienceBiochemistryInternal medicinePsychology
DOInot available

Abstract

fetched live from OpenAlex

PURPOSE: Hydrogen Sulfide has been found to be produced endogenously in amounts that cause vasodilatation. The purpose of this review is to outline the effects of hydrogen sulfide as a gasotransmitter. METHODS: This article is a summary of work done in Dr. Rui Wang's laboratory and a comprehensive review of H2S on the Pub-Med website. PRINCIPLE FINDINGS: One of the specific cellular targets of hydrogen sulfide is the K(ATP) channel protein which produces vasodilatation. The other gasotransmitters like NO (nitric oxide) interact with hydrogen sulfide in complex ways. This action could be important in hypertension and other vascular diseases. CONCLUSION: Gasotransmitter research is relevant to the pathophysiology of a number of cardiovascular disease processes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.817
Threshold uncertainty score0.440

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.184
Teacher spread0.170 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations44
Published2006
Admission routes1
Has abstractyes

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