Age dependent effects of haemorrhage on the arterial baroreflex control of heart rate in conscious lambs
Bibliographic record
Abstract
Previously, we showed that arterial pressure decreased after moderate haemorrhage in conscious lambs, whereas a compensatory increase in heart rate occurred only in newborns. These findings provided evidence to suggest an age‐dependent effect of haemorrhage on the arterial baroreflex control of heart rate. Therefore, in the present study, the arterial baroreflex was assessed in conscious lambs aged 14±1 days (G I, N=4) and 43±7 days (G II, N=6) before (control, C) and at 30 and 60 min after haemorrhage (30% of calculated blood volume). The following parameters governing the arterial baroreflex were evaluated: Heart rate range ( P1 ), slope coefficient ( P2 ), systolic arterial pressure at midpoint ( P3 ), minimum HR ( P4 ), and maximum gain ( G max ). Values are mean±SEM; *p<0.05 compared with C; †p<0.05 compared with G I. Predominant effects of haemorrhage were: a decrease in P1 which was greater in G I than G II, and a decrease in G max which was greater in G II than G I. Therefore, severe haemorrhage alters several parameters governing the arterial baroreflex control of heart rate, these effects being developmentally regulated. This research was supported by the Canadian Institutes of Health Research (CIHR).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".