Sterol Chemical Structure and Conformation Influence the Thermotropic Phase Behaviour of Dipalmitoylphosphatidylcholine Bilayers
Bibliographic record
Abstract
Studying the nature of interactions between the sterol ring system and neigbouring phospholipid molecules is important for our understanding of the properties of sterols in biological molecules and the role of such interactions in many disease processes. In this project, the thermotropic phase behaviour of binary dipalmitoylphosphatidylcholine (DPPC)/sterol mixtures with different sterol ring configurations (C5,6 double bond, 5α-H and 5β-H orientation and either 3α-OH, 3β-OH, 3-ketone functional groups) was investigated using differential scanning calorimetry (DSC) and was compared to earlier studies of cholesterol/ and epicholesterol/DPPC mixtures. Given the differences in the thermodynamic parameters obtained from these mixtures and their associated changes in bilayer stability and miscibility, it is clear that changing the sterol chemical configuration has a significant effect on bilayer properties. Any sterol molecule whose ring structure deviates from that of cholesterol is unlikely to be fully miscible in mammalian membranes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".