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Varicocele and Oxidative Stress

2012· book-chapter· en· W131934366 on OpenAlexaff
Armand Zini, Naif Alhathal

Bibliographic record

VenueHumana Press eBooks · 2012
Typebook-chapter
Languageen
FieldMedicine
TopicSperm and Testicular Function
Canadian institutionsSt Mary's Hospital Centre
Fundersnot available
KeywordsVaricoceleSpermSpermatic cordInfertilityMale infertilityAndrologyMedicineOxidative stressSemenUrologyBiologyInternal medicineSurgeryPregnancyGenetics

Abstract

fetched live from OpenAlex

A varicocele is an abnormal dilatation of the pampiniform plexus within the spermatic cord. It is the most common male infertility factor, with multiple potential etiologies involved in its development. However, despite ongoing extensive research on varicoceles, the exact mechanism(s) by which varicocele influences male fertility is not known. Recent studies have shown that infertile men with varicocele have higher levels of seminal oxidative stress (OS) markers, and/or lower seminal antioxidant levels, than do fertile men and infertile men without varicocele. The abnormally high levels of seminal OS biomarkers (e.g., reactive oxygen species, malonaldehyde) in infertile men with varicocele is clinically relevant as these markers have been associated with poor sperm function and reduced fertility potential. In addition, infertile patients with varicocele possess high levels of sperm DNA damage and the mechanism of varicocele-induced sperm DNA damage is believed to be at least in part due to OS. The observed improvement in seminal OS and sperm DNA damage after varicocele repair supports the premise that varicocele can induce seminal OS.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.028
Threshold uncertainty score0.094

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0280.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.065
GPT teacher head0.263
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2012
Admission routes1
Has abstractyes

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