Ciliary (Dys)function in Human Disease: Mapping the Ciliogenesis Pathway
Bibliographic record
Abstract
The centrosome coordinates formation of the microtubule network, a key component of the mammalian cytoskeleton. Aside from its supporting role in separating genetic material during cell division, the centrosome facilitates the formation of cilia (ciliogenesis) in non-dividing and differentiated cells. Cilia may be motile or non-motile, participating in a range of physiological activities including mucociliary transport, hearing, vision and kidney filtration processes. Ciliopathies occur when cells fail to undergo ciliogenesis or when cilia are improperly formed, affecting all of these functions to varying degrees. While there is increasing emphasis on the genetic factors contributing to these ciliopathies, many proteins involved in the cilia formation program remain elusive. The use of gene knockdown and functional assays are indispensable tools in determining how various proteins contribute to the onset of ciliopathies, ultimately laying the foundation for the development of future gene- and drug-therapy options.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".