Potential role for serum soluble CD200 in human Chronic Lymphocytic Leukemia (88.15)
Bibliographic record
Abstract
Abstract CD200, a transmembrane protein expressed on multiple cell types, regulates anti-tumor immunity in animal models. Its overexpression is associated with a poor prognosis in human AML, MM, and melanoma. Blockade of CD200 expression on CD200-expressing tumor cells using CD200-specific monoclonal antibodies or siRNA enhanced anti-tumor immunity against tumor cells both in vitro and in vivo. A soluble variant of CD200 (sCD200) is detectable in human serum, and patients with Chronic lymphocytic leukemia show elevated serum levels. We investigated the correlation between serum sCD200 levels and clinical disease in CLL patients. sCD200 levels are associated with Rai disease stage and lymphocyte-doubling time. Shedding of cell surface CD200 from CLL cells in vitro can be induced by PMA and TLR7 agonists, with patient-to-patient variability. Shedding of CD200 is correlated with patient serum sCD200 levels, suggesting that inherent differences of CLL cells in responses to shedding stimuli may have clinical significance. sCD200 levels in serum may provide prognostic and/or diagnostic information in CLL, and may contribute to the efficacy of treatments targeting cell-surface CD200.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".