Abstract 11102: Fibroblast Growth Factor-2 Attenuates Human Cardiac Fibroblast-Mediated Extracellular Matrix Remodeling
Bibliographic record
Abstract
BACKGROUND: After MI, elevation of profibrotic transforming growth factor-β1 (TGF-β1) results in myofibroblast-mediated matrix remodeling and progression of heart failure. In this study, we examined the effects of fibroblast growth factor (FGF-2) on human cardiac fibroblast (CF) mediated extracellular matrix (ECM) remodeling. METHOD/RESULTS: Human CF from atrial or ventricular heart biopsies were seeded into 3D collagen matrices. Myofibroblast activation was functionally assessed by the extent of matrix contraction. As compared to baseline myofibroblast activity, FGF-2 attenuated TGF-β1 mediated myofibroblast activation in both atrial (1.06±0.09 versus 1.17±0.09, P<0.0001) and ventricular fibroblasts (1.12±0.04 vs. 1.51±0.27, P<0.05). New collagen synthesis was assessed by 3H-proline incorporation. Fibroblasts treated with TGF-β1 had increased collagen synthesis while FGF-2 reduced collagen synthesis (P<0.05). ECM dysregulation was investigated by in situ zymography. TGF-β1 increased total protease activi...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".