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Record W143669294

Non-Destructive Bio-Assay of Single Living Cell

2012· dissertation· en· W143669294 on OpenAlexfundno aff
Vahé Nerguizian

Bibliographic record

VenueSpectrum Research Repository (Concordia University) · 2012
Typedissertation
Languageen
FieldEngineering
TopicMicrofluidic and Bio-sensing Technologies
Canadian institutionsnot available
FundersÉcole de technologie supérieure
KeywordsMicrofluidicsDielectrophoresisCirculating tumor cellComputer scienceMicrochannelPoint of careNanotechnologyBiochemical engineeringBiomedical engineeringElectronic engineeringMaterials scienceMedicineEngineeringCancerPathology
DOInot available

Abstract

fetched live from OpenAlex

For more than a decade, researchers are trying to find out practical commercial tool for particle/cell detection and characterization with portable, low cost, specific and sensitive characteristics. The advance of Micro Electro Mechanical Systems (MEMS) and microfluidic technologies opened a major challenge for a large number of researchers, industrial health and bio companies to invest their time and budget into the avenue of point of care health instruments or devices helping the early detection of cancer cells within the human blood via circulating malignant cells. \nActual existing commercial flow cytometer that detects and identifies the type and size of cells are costly, time consuming and need the assistance of highly qualified operators. Moreover, in certain research activities, micro cytometers are investigated and assessed with different detection techniques such as optical, impedance spectroscopy, electromagnetic spectroscopy and many other techniques. \nThe aim of this research is to investigate an innovative mechanism that enables to characterize, identify and differentiate among various living cells including malignant tumor cells through the use of the electromagnetic energy detection technique. Cells are spatially centered in a microfluidic channel through dielectrophoresis technique then detected and characterized by measuring and interpreting the RF signal transmission of the cells passing one by one through the interrogation region in the microchannel. \n\tThe outcome of this research might help the clinical end user to gain certain important information about the condition of the patient, establish personalized treatment or track the effect of a treatment. Detection and counting of tumor cells may help identification of early stages of illness and help patient with early care that may significantly cut the overall cost of cancer management.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.229
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2012
Admission routes1
Has abstractyes

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