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The Effect of Wild Blueberry Juice Consumption in Women at Risk for Type 2 Diabetes

2015· article· en· W1446649639 on OpenAlexaff
Kim S. Stote, Marva Sweeney‐Nixon, Terri Kean, David J. Baer, Janet A. Novotny, NL Flaherty, Akshaya Chandrasekaran, Pauline M. Carrico, Melendez Ja, Kathy T Gottschall‐Pass

Bibliographic record

VenueThe FASEB Journal · 2015
Typearticle
Languageen
FieldMedicine
TopicPhytochemicals and Antioxidant Activities
Canadian institutionsUniversity of Prince Edward Island
Fundersnot available
KeywordsType 2 diabetesMedicineDiabetes mellitusOxidative stressInsulin resistanceBlood pressureInternal medicinePlaceboInflammationInsulinEndocrinologyBiomarkerPhysiologyBiologyBiochemistryPathology

Abstract

fetched live from OpenAlex

Wild blueberries have a high content of polyphenols, but there is limited data evaluating their health benefits in people at risk for type 2 diabetes. The objective of the study was to investigate whether 100% wild blueberry juice (WBJ) consumption causes biomarker changes in glucoregulatory control or in those that reflect protection against oxidative stress, inflammation or vascular status, all of which are associated with diabetes risk. A single‐blind randomized cross‐over design study was conducted in which women (n = 19, ages 39‐64 y) at risk for type 2 diabetes consumed 240 ml WBJ or 240 ml of a control beverage as part of their free‐living diet for 7 days. Outcome variables included biomarkers of glucose regulation, oxidative stress, and inflammation. Vascular status, assessed by EndoPat, and blood pressure were also evaluated. WBJ consumption produced no significant changes in biomarkers of glucose regulation and surrogate markers of insulin resistance (glucose, insulin, HOMA‐IR and QUICKI); oxidative stress (total 8‐isoprostanes and LDL‐oxidation); inflammation (IL‐6, IL‐10, CRP, TNF‐alpha, ICAM, VCAM, SAA); and vascular status. However, WBJ consumption showed a trend for lowering systolic blood pressure when compared to the control beverage: 120.8 ± 2.2 mmHg in the placebo group vs 116.0 ± 2.2 mmHg in the WBJ group ( P = 0.088). Short term intake of WBJ consumption did not have harmful effects on biomarkers of glucose regulation, oxidative stress, inflammation and vascular status in women at risk for type 2 diabetes. In addition, WBJ may improve systolic blood pressure.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.283
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2015
Admission routes1
Has abstractyes

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