Kidney function and sulphate transport in Pacific Hagfish (Eptatretus Stoutii)
Bibliographic record
Abstract
The hagfish diverged from vertebrate lineage ~550–600 mya and therefore represent a unique model to study early ionoregulatory strategies. Whilst hagfish are osmoconformers for Na+ and Cl−, these animals have plasma concentrations of the divalent (Ca2+, Mg2+ and S042‐) ions at 1/3 to 1/2 seawater. A difficulty in molecular research involving hagfish is the lack of genomic information. Using a recently obtained hagfish Illumina transcriptome, we have identified a putative sulfate transporter (SLC26a1). We investigated if hagfish possess active S042‐ handling mechanisms by injecting a chronic (3 day) S042‐ load to upregulate potential S042‐ handling and transporting abilities. Using 3H‐ inulin and 35S (as S042‐) injections into the blood, we monitored both GFR and net S042‐ excretion. We also investigated the changes in expression of hfSLC26a1. We determined that Pacific hagfish have a relatively high GFR (~ 0.46 mls/kg/h) despite being osmoconformers and are able to increase sulfate excretion/handling following chronic S042‐loading from 0.06 umol/kg/h to 0.28 umol/kg/h.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".