Compositae-Associated Allergic Contact Dermatitis from Bisabolol
Bibliographic record
Abstract
BACKGROUND: Compositae-related chemicals cause allergic contact dermatitis (ACD) in children with atopic dermatitis (AD). Moisturizers can be an overlooked exposure source. OBJECTIVE: To evaluate ACD in children with recalcitrant AD and a reported history of intolerance to Aquaphor Healing Ointment (AHO) moisturizer. METHODS: We retrospectively reviewed charts of children patch-tested to the ingredients of AHO moisturizer who had a history of intolerance, as well as of additional patch-tested patients with exposure to bisabolol in their personal hygiene products and without a history of product intolerance. RESULTS: Seven patients, six of whom had AD, had been referred to our clinic with a history of intolerance to the moisturizer. They were patch-tested with their moisturizer and the components provided by Beiersdorf. Of these, four had positive reactions to their AHO moisturizer and to bisabolol, a Compositae derivative. CONCLUSION: Bisabolol, a sesquiterpene alcohol, should be considered a potential cause of ACD in children with AD and a history of moisturizer intolerance.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".