Bibliographic record
Abstract
Cellular survival and homeostasis is achieved due to the complex network of proteins present within cells to regulate responses to external stimuli. The phosphatidylinositol-3'-OH kinase (PI3' K) and the Wnt/Wg pathways, incorporate many important effector molecules and regulatory proteins to govern such cellular events as survival, apoptosis, cell-cell communication and fate determination. Protein kinase B (PKB) and glycogen synthase kinase-3 (GSK-3)/Shaggy are the main effector molecules in the PI3'K and Wnt/Wg pathways respectively, and rely on interactions with numerous regulatory proteins for initial phosphorylation or dephosphorylation, and subsequent activation. Integrin linked kinase (ILK) has been shown to act upstream of both PKB and GSK-3/Shaggy in mammalian systems, and regulates them in a PI3'K dependent manner and has been postulated as a PI3'K dependent protein kinase-2 (PDK-2) molecule. Studies with Drosophila ILK (D ILK) further validate this idea. In the present study, it is shown that DILK is 59% similar to human ILK and is regulated in a PI3'K dependent manner in vivo. DILK is able to phosphorylate PKB in vitro and this occurs at serine-505 residue, the Drosophila homologue to mammalian serine-473, in vivo. DILK was also shown to phosphorylate Shaggy, the GSK-3 homologue, in vitro. In addition, it was illustrated that insulin and wortmannin, PI3' K specific activator and inhibitor respectively, affect various genes at the nuclear level. Using microarray technology, insulin and wortmannin were shown to regulate the expression of 1151 genes, of which two were chosen for further verification by RT-PCR. Dream was verified to be up-regulated by insulin and the functional significance of this effect still remains to be determined.Dept. of Biological Sciences. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2004 .S74. Source: Masters Abstracts International, Volume: 43-03, page: 0788. Adviser: Adnan Ali. Thesis (M.Sc.)--University of Windsor (Canada), 2004.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".