Efficacy and safety of temsirolimus in renal cell carcinoma
Bibliographic record
Abstract
Temsirolimus is a novel intravenous targeted therapy that inhibits the mammalian target of rapamycin kinase. This kinase is a part of the phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin pathway, which plays a key role in cell proliferation, metabolism and angiogenesis. Temsirolimus has shown activity in renal cell carcinoma (RCC) and mantel cell lymphoma and is approved as first line treatment in advanced RCC with poor prognostic factors. This review focuses on the clinical use of temsirolimus in RCC, its safety and possible mechanisms of resistance. Keywords: renal cell carcinoma; mTOR inhibitors; efficacy; safety. Received: May 18, 2014; Accepted: July 28, 2014; Published: April 9, 2015 Corresponding Author: Michael Vickers MD, MPH, FRCPC, Medical Oncologist, The Ottawa Hospital Cancer Center, 501 Smyth Road, Ottawa, ON, Canada, K1H 8L6. E-mail: mvickers@toh.on.ca .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".