Breast Cancer Metastases to Bone: Role of the Microenvironment
Bibliographic record
Abstract
IntroductionBone is the preferred site for breast cancer metastasis, which leads to altered mineral metabolism, disruption of bone architecture, and considerable pain burden.Prior to homing to the bone, the primary breast tumour releases soluble factors that lead to the creation of a pre-metastatic niche in the bone, which then serves to attract and maintain invading breast cancer cells.Breast cancer cells actively influence resident bone cells, altering both the action of and cross-talk between bone forming osteoblasts and bone-destroying osteoclasts.Breast cancer cells inhibit osteoblast differentiation and prevent them f r o m c r e a t i n g a n d mineralizing new bone.Immature osteoblasts act as part of a hematopoietic stem cell niche and provide an attachment site for breast cancer cells.Breast cancer cells also produce factors, such as parathyroid hormone-related protein (PTHrP), which induce osteoblasts to stimulate the production of the pro-resorptive cytokine RANKL and to inhibit the production of RANKL inhibitor, OPG.RANKL, together with other osteoclastogenic factors released from breast cancer cells, promotes the fusion and differentiation of osteoclasts, resulting in bone destruction.As a result of bone resorption, growth factors stored in the bone matrix, such as TGF, are released and can further stimulate the proliferation and survival of tumour cells.Thus, the complex interactions between breast cancer cells and the bone microenvironment underlie the homing of the breast cancer to bone and the subsequent progression of osteolytic lesions.Current therapeutics against bone metastases aim to prevent osteoclastic bone resorption by blocking osteoclast differentiation or stimulating their apoptosis.The osteoblast provides a valuable potential target, as a source of osteoclastic differentiation factors, and a platform for cancer cell attachment.Recent results from basic and clinical research provide new targets to prevent the interactions between breast cancer cells and the bone microenvironment at different stages of the metastatic cascade. Chapter outline Physiological regulation of breast and bone Breast Growth and Development -Interactions of normal breast tissue with bone -Breast carcinoma Bone Microenvironment www.intechopen.com
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".