Transfusion‐Associated Graft‐Versus‐Host Disease and Microchimerism
Bibliographic record
Abstract
Transfusion-associated graft-versus-host disease (TA-GVHD) is an acute illness characterised by fever, rash, pancytopenia, diarrhoea and liver dysfunction which begins 4-30 days (median 8-10 days) after transfusion and results in death within three weeks from symptom onset in over 90% of the cases. Patients at increased risk for TA-GVHD include those who are immune impaired and those receiving blood components donated from blood relatives. Fetuses and neonates have immature immune systems and may be at increased risk of TA-GVHD. In neonates, most cases of TA-GVHD reported are in those with congenital immunodeficiency or who received products from related donors. Transfusion-associated microchimerism (MC) has been reported mostly in trauma patients, but has also been reported in sickle cell disease and thalassaemia patients. Irradiation of products prevents TA-MC. Leucocyte reduction of blood products alone does not decrease the incidence of TA-MC among trauma patients. In addition, TA-MC can be sustained for decades after transfusion.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.020 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".