CD34 family proteins are key regulators of inflammatory cell migration and vascular integrity (173.17)
Bibliographic record
Abstract
Abstract CD34 is a widely used marker of hematopoietic progenitors and vascular endothelia yet its function remains obscure. CD34 is the founding member of a family of three proteins (CD34, Podocalyxin and Endoglycan) with overlapping expression patterns and we have used gene targeting to investigate the function and redundancy of these proteins. We find that CD34 is uniquely expressed by mast cells, eosinophils and dendritic cells and that mice lacking CD34 are remarkably resistant to a variety of mucosal inflammatory diseases including allergic asthma, hypersensitivity pneumonitis and colitis. Resistance reflects defective inflammatory cell trafficking due to enhanced adhesion and impaired chemotaxis and these defects can be reversed through ectopic expression of a human CD34 transgene. Podocalyxin, in contrast, is uniquely expressed by a variety of embryonic tissues and inactivation of the Podxl gene leads to perinatal lethality due to a failure of tissues to undergo appropriate morphogenesis. To investigate the function of Podocalyxin (and CD34) on adult vasculature we have generated mice that selectively inactivate the encoding gene in endothelia. These exhibit excessive vascular leakage and develop an emphysema-like phenotype due to poor vessel patency in the lung. In summary, CD34 type proteins play critical roles in a variety of normal developmental processes and immunity. Mechanistically, they act as key regulators of cell adhesion, cell chemotaxis and morphogenesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".