Gene reactivation diminishes delta-modulated high frequency oscillations during seizure-like events in Mecp2-deficient mice
Bibliographic record
Abstract
Genetically modified Mecp2-deficient mice provide a unique model of epilepsy associated with Rett syndrome. Examination of intracranial electroencephalogram (iEEG) recordings from mice lacking mecp2 function have revealed the presence of spontaneous epileptiform activity. To date the majority of these studies have focused on the low frequencies oscillations (LFOs), however, recent findings suggest there may be a link between high frequency oscillations (HFOs) and epileptogenesis. In this study the coupling of LFO phase to HFO amplitude was examined and identified modulation of HFO amplitude (400-600 Hz) by the phase of the high delta band (3-6 Hz) in male Mecp2-deficient mice diminishes after mecp2 gene reactivation therapy. These delta-HFO modulations were found to be strongly associated with long duration epileptiform discharges found primarily in the male non-rescue Mecp2-deficient mice. Differences in HFO interactions with high delta LFOs in male non-rescue and rescue mice could potentially be used as a biomarker for identifying the presence of seizure activity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".