Human Parechoviruses, New Players in the Pathogenesis of Viral Meningitis
Bibliographic record
Abstract
Human parechoviruses (HPeVs) belong to the family of Picornaviridae and have been recognized as a separate group on the basis of distinct molecular and biological properties since 1999. The identification of HPeV3 in 2004 and its association with neonatal sepsis and meningitis made it particularly clear that HPeVs are related to severe disease in infants. Molecular techniques are increasingly being used for the identification of HPeVs and with the increase in epidemiological and clinical data, HPeVs are now considered to be the second predominant cause of viral meningitis, following enteroviruses (EVs). This review focuses on the role of HPeVs, with particular notice to HPeV3, as a causative agent in viral meningitis as well as neonatal sepsis and encephalitis. Data on epidemiology, clinical manifestations, immunology and molecular and cellular biology, underlying the greater pathogenicity of this novel group of viruses as well as the diagnosis, management and treatment options will be discussed.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.009 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".