An essential role for endothelial TLR4 in leukocyte recruitment
Bibliographic record
Abstract
Recent work from our laboratory suggested that neutrophil recruitment into the lungs in response to systemic lipopolysaccaride was not due to TLR4 on leukocytes but rather on radiation‐resistant cells (eg. mast cells, endothelium, epithelium or fibroblasts). In this study we made a transgenic mouse that has TLR4 exclusively on endothelium (endo TLR4). These mice had no TLR4 on any leukocyte population but did have LPS responsive endothelium. LPS increased neutrophil recruitment into lungs in wild‐type but not in TLR4 deficient mice. Transgenic (endo TLR4) mice responded almost identically to wild‐type mice in terms of neutrophil recruitment into lungs. Examination of local LPS responses in muscle also revealed that wild‐type and transgenic endo TLR4 mice recruited ample neutrophils whereas TLR4 deficient mice had no responses. Our data suggest a very robust and effective neutrophil recruitment response when endothelium were the only cells expressing TLR4. The data further support the importance of endothelial TLR4 in innate immune responses.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".