Abstract 15623: Angiopoietin Like-2 Knockdown Worsens Pressure Overload-Induced Cardiac Dysfunction Despite Preserving Vascular Endothelial Integrity in Mice
Bibliographic record
Abstract
Background: High circulating levels of angiopoietin-like 2 (angptl2), a pro-inflammatory protein, have been associated with obesity, diabetes and atherosclerosis. In mice, angptl2 induces vascular inflammation and endothelial dysfunction, but the impact of angptl2 on cardiac function is still unknown. Since mechanical stress has been shown to promote angptl2 expression and tissue remodeling, we hypothesized that angptl2 could contribute to cardiac dysfunction and that knocking down angptl2 would be protective against pressure overload. Methods/Results: We investigated both cardiac and vascular endothelial functions in angptl2 knockdown mice (KD) versus wild-type (WT) littermates, in response to a 6-week pressure overload induced by transverse aortic constriction (TAC). While peripheral blood pressure was not affected by TAC, systolic pressure in the right carotid artery was increased by 60 % in WT, but only by 28 % in KD mice (p<0.05 vs. WT, n=8). In WT, but not in KD mice, carotid and posterior cerebral ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".