Photodynamic Therapy: Light Delivery and Dosage for Second‐Generation Photosensitizers
Why this work is in the frame
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Bibliographic record
Abstract
With the development of new photosensitizers that have enhanced photoactivation at longer wavelengths than haematoporphyrin derivative, new considerations arise in the light source and delivery systems and in the techniques for physical dosimetry and in vivo optical measurements in photodynamic therapy. The limitations and future potential of solid-state laser sources are presented. The relationships between photosensitizer photoactivation characteristics and the effective photodynamic treatment volume are developed and discussed quantitatively. The problems in defining and measuring the photodynamic dose are examined, and potential techniques for measuring the factors involved in this are evaluated with emphasis on noninvasive approaches which may be used clinically.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it