A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
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Abstract
Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD.
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The record
- Venue
- Science
- Topic
- Genetic Associations and Epidemiology
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of Ottawa
- Funders
- National Heart, Lung, and Blood Institute
- Keywords
- AlleleCDKN2AGeneticsChromosomeCDKN2BCoronary heart diseaseInternal medicineBiologyGeneChromosome 9DiseaseMedicine
- Has abstract in OpenAlex
- yes