Bibliographic record
Abstract
This chapter explores how bioconjugation chemistry can be used to covalently attach biologically relevant molecules to dendrimers. It also explores how the specific conjugation chemistries are determined based on the application, the chemical functionalities available on the molecules of interest and those on the dendrimer's focal point or periphery. First, the chapter discusses the conjugation of drug molecules. This is followed by carbohydrates, imaging agents, oligonucleotides, and peptides/proteins. The impact of the conjugation chemistry on the biological properties of the resulting molecules is illustrated through selected examples. Among the currently studied drug delivery systems, dendrimers have emerged as an attractive class of materials, mainly because of their well-defined structures. Doxorubicin (DOX) is a chemotherapeutic commonly used in the treatment of hematological malignancies. Deoxyribonucleic acid (DNA) is a polymer composed of a sequence of nucleotide repeat units that provide a sugar– phosphate backbone and pendant nucleobases.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.101 | 0.025 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".