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Record W1506241819 · doi:10.5772/33005

Association Mapping in Plant Genomes

2012· book-chapter· en· W1506241819 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueInTech eBooks · 2012
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Mapping and Diversity in Plants and Animals
Canadian institutionsAgriculture and Agri-Food Canada
Fundersnot available
KeywordsAssociation (psychology)BiologyComputational biologyGenome-wide association studyGenomeGeographyEvolutionary biologyGeneticsPsychologySingle-nucleotide polymorphismGenotypeGene

Abstract

fetched live from OpenAlex

One of the many goals of plant geneticists and breeders pertains to the explanation of phenotypic variation as it relates to changes in DNA sequence (Myles et al., 2009). The development of molecular markers for the detection and exploitation of DNA polymorphisms in plant systems is one of the most significant developments in the field of molecular biology and biotechnology. Linkage mapping has been a key tool for identifying the genetic basis of quantitative traits in plants. However, for linkage studies, suitable crosses, sometimes limited by low polymorphism or small population size, are required. In addition, only two alleles per locus and few recombination events are considered to estimate the genetic distances between marker loci and to identify the causative genomic regions for quantitative trait loci (QTL), thereby limiting the mapping resolution. To circumvent these limitations, linkage disequilibrium (LD) mapping or association mapping (AM) has been used extensively to dissect human diseases (Slatkin, 2008). This approach has received increased attention during the last few years. AM has the potential to identify a single polymorphism within a gene that is responsible for phenotypic differences. AM involves searching for genotype-phenotype correlations among unrelated individuals. Its high resolution is accounted for by the historical recombination accumulated in natural populations and collections of landraces, breeding materials and varieties. By exploiting broader genetic diversity, AM offers three main advantages over linkage mapping: mapping resolution, allele number and time saving in establishing a marker-trait association and its application in a breeding program (Flint-Garcia et al., 2003). Although AM presents clear advantages over linkage mapping, they are often applied in conjunction, especially to validate the associations identified by AM, thus reducing spurious associations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.940
Threshold uncertainty score0.830

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.212
Teacher spread0.190 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it