Is sustained post‐exercise vasodilation associated with an exercise‐induced mast cell activation? (1106.19)
Bibliographic record
Abstract
An acute bout of aerobic exercise elicits a sustained post‐exercise vasodilation which is histamine‐receptor mediated. However, the source of the histamine which activates histamine receptors during recovery from exercise remains unknown. One possible source is degranulation of mast cells. We tested the hypothesis that tryptase, a marker of mast cell degranulation, is elevated during or after exercise. In 11 healthy subjects (6 men; 5 women), we measured interstitial tryptase via microdialysis of the vastus lateralis before, during, and through 90 min after exercise (1 hr of unilateral dynamic knee extension at 60% of peak power; 6 subjects) or rest (1 hr seated upright; 5 subjects). Compared with baseline, interstitial tryptase was increased more during exercise (Δ 60 ± 7%) than during rest (Δ 10 ± 9%, P < 0.05) and tended to remain elevated during recovery (exercise Δ 44 ± 14% vs rest Δ 16 ± 7%, P = 0.11). Thus, localized mast cell degranulation occurs in exercising muscle, and appears to contribute in part to sustained post‐exercise histaminergic vasodilation. This suggests that exercise produces an anaphylactoid signal which may influence skeletal muscle blood flow during exercise. Grant Funding Source : NIH grant HL115027
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".