Intravenous mesenchymal stem cell administration spurs endogenous hepatic mitochondrial gene expression in the diet‐induced obese mouse (693.10)
Bibliographic record
Abstract
Intravenous human mesenchymal stem cell (MSC) administration alleviates hepatic oxidative stress in the diet‐induced obese mouse. However, the underlying mechanisms responsible for these benefits are uncertain. Possible explanations range from direct cell engraftment to paracrine‐mediated endogenous cell stimulation. To examine this question, male C57BL/J mice (n=24) were assigned to one of two dietary groups; chow (10% kcal fat) and high fat (60% kcal fat) for 12 wk. Animals were further divided, receiving intravenous saline (0.2 mL PBS) or MSC (750,000 cells). Post‐injection (24 h), qRT‐PCR was used to identify changes in endogenous (mouse) and exogenous (human) transcripts for glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) and mouse mitochondrial protein cytochrome c oxidase subunit II (COX‐II) in the liver. Human GAPDH and COX‐II were detected in the livers of animals undergoing MSC treatment indicating successful cell targeting. Declines in mouse COX‐II caused by HF were mitigated by MSC therapy (p<0.05). Results indicate that MSC administration triggers endogenous mitochondrial gene proliferation which may explain the ability of MSC to mitigate hepatic oxidative stress in diet‐induced obesity. Grant Funding Source : Supported by MitoCanada
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".