Abstract 15350: Progressive Aortic Dilatation is Regulated by the mir-17 Cluster
Bibliographic record
Abstract
Introduction: Ascending aortic aneurysms dilate due to activation of matrix metalloproteinase (MMPs), and matrix disruption. MicroRNAs (miRNAs) may contribute to the pathogenesis of aortic dilatation, but the specific miRNAs responsible have not been determined. We aimed to identify the miRNAs associated with progressive aortic dilation in patients with Marfan syndrome and bicuspid aortic valve (BAV) aortopathy. Methods and Results: Aortic tissue samples (~1х1cm) were collected from the dilated aneurysmal segment and adjacent nondilated segment which appeared normal at aortic surgery. The nondilated segments represent the early stages of aortic matrix degradation (before dilatation) and the dilated segment represents the late stage after aortic remodeling. Fourteen sample pairs were collected from BAV patients and 8 pairs from Marfan patients. miRNA levels were determined by Affymetrix GeneChip miRNA 3.0 Array for miRNA profiling. miRNA expression in the nondilated were compared to the dilated segments. T...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".