Abstract 13353: Methylglyoxal Induces Stem Cell Dysfunction Through Impaired Matrix Interactions After Myocardial Infarction
Bibliographic record
Abstract
Background: Advanced glycation end-products (AGEs) have been associated with poorer outcomes in heart failure (HF) after myocardial infarction (MI). The contribution of AGEs to post-MI injury has yet to be shown. Methylglyoxal (MG) is considered the most important AGE precursor. To elucidate the role of MG in post-MI repair, this study used a mouse model that over-expresses the MG-metabolizing enzyme glyoxalase-1 (GLO1). Methods/Results: MI was induced in GLO1 over-expressing mice and their wild-type (WT) littermates. MI resulted in increased MG levels in hearts of both mouse groups. Left ventricular ejection fraction was superior in GLO1 mice (46.0±3.3%) compared to WT (33.9±1.8%, p=0.008) at 4 weeks post-MI. GLO1 mice also had smaller infarcts (41.5±2.2% vs. 57.3±7.1%, p=0.05) and improved chamber volumes. Immunohistochemistry at 4 weeks post-MI revealed greater arteriole (p=0.006) and capillary (p=0.03) density in GLO1 vs. WT mice, and an overall reduction in cardiomyocyte death through apoptosis (p=0....
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".