Sendai Virus Binds to a Dispersed Population of NBD-GD1a
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Receptor aggregation is believed to be an important step in the attachment of membrane enveloped virus' to target cell membranes. A likely receptor for Sendai virus is the ganglioside GD1a. In this work we have studied the membrane diffusion of the fluorescent ganglioside NBD-GD1a on the surface of CV-1 cells with standard photobleaching techniques. Using confocal laser scanning microscopy (CLSM) and Image Correlation Spectroscopy (ICS) NBD-GD1a is shown to exist in at least two populations: dispersed and aggregated. By quantifying the distribution of NBD-GD1a pre- and post-incubation with Sendai virus it is shown that the virus induces a dose-dependent clustering of NBD-GD1a. Image cross-correlation spectroscopy (ICCS) is used to further quantitatively characterize this clustering by demonstrating that it occurs due to binding of virus to the dispersed population of NBD-GD1a.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it