Abstract 16452: Determinants of Vt Occurrence in Patients With Nonischemic and Dilated Cardiomyopathy: Insights From the Study of Explanted Human Hearts
Bibliographic record
Abstract
Introduction: The molecular and cellular determinants of ventricular tachycardia (VT) in patients with non-ischemic dilated cardiomyopathy (NIDCM) remain poorly defined. Hypothesis: Patients with idiopathic NIDCM and significant VT display different tissue and electrical remodeling when compared to other NIDCM patients with end stage heart failure but no history of ventricular arrhythmias. Methods: History of clinically-significant VT was defined as symptomatic VT, cardiac arrest with documented VT/ventricular fibrillation or appropriate defibrillator shocks. A total of 21 explanted hearts were analyzed (VT=10, no VT=11) in a double-blind, case control study design. The molecular, cellular and histological features of adverse myocardial remodeling were assessed. Results: The two groups were closely matched in sex (male= 80% vs 72%), LVEF (20.8% vs 20.6%, p=0.6), LVAD use (4/10 vs 6/11, p=0.66), and optimal medical therapy. Explanted hearts from patients with VT showed greater hypertrophic changes based on...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".