Double Strand Break Signaling in Health and Diseases
Bibliographic record
Abstract
2.1 Sensing the DNA double strand breaks When DSBs are generated they are initially recognized by either the Ku70/Ku80 heterodimer, the Mre11-Rad50-NBS1 (MRN) complex or members of the PARP (PARP1/2) family of proteins The role of these protein sensors is to bind to and tether the DNA ends, thereby preventing further breakage as well as to recruit additional proteins that are required for DSB signaling and repair. The first group of proteins to be recruited to DSBs after initial sensing of the breaks belongs to the phosphatidylinositol-3kinase-like protein kinases family. These include ATM (ataxia-telangiectasia mutated), ATR (ATM and Rad3-related) and the catalytic subunit of DNA-PK known as DNA-PKcs. While ATM and DNA-PK respond only to DSBs, ATR also responds to single strand DNA breaks.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".