Absorption of sugarcane policosanols in golden syrian hamsters
Bibliographic record
Abstract
Supplementation with Cuban sugarcane policosanols (PC) has been shown to reduce total cholesterol and LDL‐C up to 23 and 31%, respectively. PC ability to decrease cholesterol levels stems from evidence showing that PC inhibit cholesterol biosynthesis. Octacosanol (C28) is believed to be the primary PC responsible for efficacy since the concentration of C28 is markedly larger compared to other PC found within the supplement. Nonetheless, intestinal absorption of PC could be limited by their hydrophobic nature, secondary to their aliphatic, saturated molecular structure. The objective of the present study was to evaluate levels C28 in the small intestine, liver, perirenal adipose, plasma and feces of male Golden Syrian Hamsters (N=36) fed diet containing no PC or 0.275 mg/g of either Cuban sugarcane PC or non‐Cuban sugarcane PC. A subset of 6 hamsters receiving non‐Cuban PC was fed 2.75 mg PC/g of diet. Results indicated that C28 was undetectable in tissues and plasma of animals supplemented with PC regardless of the brand or dosage. Fecal analysis revealed C28 was excreted 43% (P = 0.01) faster in animals receiving Cuban PC compared to those fed 0.275 mg PC/g non‐Cuban PC. Furthermore, C28 excretion was 38% (P = 0.05) faster in the Cuban PC group compared to the non‐Cuban group receiving 2.75 mg PC/d of diet. The results from this study suggest that insufficient amounts of supplemental PC are absorbed to elicit an effect on endogenous cholesterol biosynthesis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".