Abrogation of the Antibenzylpenicilloyl (BPO) IgE Response with BPO-Polyvinyl Alcohol Conjugates
Bibliographic record
Abstract
IgE antibodies to the benzylpenicilloyl (BPO) determinant and ovalbumin (OA) were readily induced B6D2F1 mice by a single i.p. injection of 10 µg of BPO4-OA suspended with 1 mg AI(OH)3 in 0.5 ml of saline. The potential of these mice to mount a de novo anti-BPO IgE antibody response was specifically abrogated by pretreatment of mice with tolerogenic conjugates consisting of the hapten coupled to the hydrophilic and nonimmunogenic polymers, polyvinyl alcohols (PVA), with average molecular weigths of 10,000 or 14,000 daltons. The average epitope density of these conjugates varied from 1.1 to 3.9. It is noteworthy that even BPO1.1-PVA, which elicied only weak PCA reactions in rats sensitized i.d. with mouse anti-BPO reaginic antibodies, was highly tolerogenic. More importantly, the ongoing anti-BPO reaginic response in sensitized mice was also readily suppressed by administration of these tolerogenic conjugates, e.g. a single dose of 100 µg of BPO2.7-PVA was sufficient to abolish an ongoing anti-BPO IgE response. Moreover, administration of these tolerogenic conjugates into mice sensitized to BPO4-OA, prior to their resensitization in presence of Bordetella pertussis, protected these animals from anaphylactic death on i.v. challenge with 2 mg of the polyvalent BPO9-MγG conjugate (MγG = mosue γ-globulins); by contrast, all control mice which had not received this tolerogenic regimen died of anaphylaxis. It is suggested that conjugates of PVA with haptenic antibiotic or other drug molecules may prove to be effective therapeutic agents for the specific suppression of IgE antibodies mediating allergies of the immediate type to a wide spectrum of low molecular weight allergenic compounds.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".