PRIMER REPORTE EN VENEZUELA DEL SÍNDROME DE EMACIACIÓN MULTISISTÉMICO POST-DESTETE PORCINO
Bibliographic record
Abstract
En anos recientes el Sindrome Multisistemico de Emaciacion Post Destete Porcino (PMWS) ha tenido importancia en la industria porcina en muchos paises, particularmente en Canada, Europa, Estados Unidos de America, Asia y Sur America. El sindrome afecta cerdos jovenes, principalmente entre 6 y 14 semanas de edad. El PMWS esta caracterizado por emaciacion, neumonia, diarrea, ictericia y aumento de volumen de los linfonodulos. El sindrome ha sido asociado con un circovirus porcino tipo 2 (PCV2) y, simultaneamente pueden ocurrir otras enfermedades: parvovirus porcino, virus del sindrome respiratorio y reproductivo porcino (PRRS), etc. El diagnostico del PMWS se basa en la edad de los cerdos afectados, la tipica apariencia de emaciacion, hallazgos de necropsia, histopatologicos, y examenes de Hibridacion in situ (HIS) en tejidos que revelan la presencia de PCV2. El presente estudio se realizo en 12 lechones de 8 a 12 semanas de edad, ubicados en 3 granjas porcinas de estados centrales de Venezuela (Aragua/Carabobo). Los lechones presentaban signos de consuncion, palidez generalizada, disnea, diarrea e hipertrofia de linfonodulos superficiales inguinales. A la necropsia se evidencio neumonia con pulmones no colapsables e incremento de tamano de linfonodulos inguinales, mesentericos y traqueobronquiales; mientras en la histopatologia se evidencio deplecion linfoide con perdida de la arquitectura folicular en linfonodulos, bazo y placas de Peyer, con presencia de infiltracion histiocitaria, celulas sincitiales y corpusculos intensamente basofilos intracitoplasmaticos en histiocitos, lo cual es altamente sugestivo de PMWS. Adicionalmente se procesaron muestras de estos mismos tejidos mediante una tecnica de HIS, que permitio demostrar la presencia de PCV2 en los tejidos linfoides afectados y confirmar el diagnostico de PMWS. Esta es la primera descripcion de esta entidad patologica en Venezuela. Postweaning Multisystemic Wasting Swine Syndrome, First Report in Venezuela Abstract In recent years Post Weaning Multisystemic Wasting Syndrome has become of significant concern in the swine industry in many countries, particularly Canada, United States of America, Europe, Asia and South America. The syndrome affects pigs mainly between 6 and 14 weeks of age. It is characterized by wasting, pneumonia, diarrhea, jaundice and enlarged lymph nodes. The syndrome has been associated with a porcine circovirus type 2 (PCV2) and simultaneous infections with porcine parvovirus (PPV), porcine reproductive and respiratory syndrome virus (PRRS) etc. The diagnosis of PMWS syndrome is based on the age of affected pigs, typical wasting appearance and necropsy lesions, histopathologic study and in situ hybridization (ISH) of affected tissues, showing the presence of PCV2 by HIS methods. The present study was performed in 12 piglets between 8 and 12 weeks of age, located in 3 porcine farms from Central States of Venezuelan (Aragua/Carabobo). The pigs showed signs of comsumption, pallor, dispnea, diarrhea, and enlarged superficial inguinal lymph nodes. At necropsy there was evidence of pneumonia with noncolapsable lungs as well as inguinal, mesenteric and tracheobronchial lymph nodes enlargement The histopathology study showed lymphoid depletion, with loss of follicles architecture in lymph nodes, spleen, and Peyer´s patches, histiocytic infiltration, sincitial cells and basophilic cytoplasmic inclussions in histiocytic cells. The findings described are suggestive of PMWS. The same tissues specimen were processed by a technique of IHS and revealed the presence of PCV2 in the affected lymphoid tissues to confirm the diagnosis of PMWS. This is the first description of the syndrome in Venezuela.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".