Abstract 15690: Statins as Potential Farnesoid X Receptor Modulators in Atrial Cardiomyocytes: A Gender, Age and miR328 Controlled Response
Bibliographic record
Abstract
Farnesoid X receptor (FXR) plays an important role in lipid and glucose metabolism and statins are known negative regulators of FXR expression. The role of FXR in atrial fibrillation (AF) has not been defined. MicroRNA-328 (miR-328) a small non-coding RNA contributes to adverse electrical remodeling in AF a common complication after coronary artery bypass grafting (CABG). The present study aimed to examine the levels of FXR mRNA and miR328 in 30 consecutive patients undergoing CABG. The patients group was made up of 10 women and 20 men with a mean +/-SEM. age of 68.5+/-2.1 and 64.3+/-2.3 years respectively, 14 of them on statin therapy. We analyzed right atrial biopsies taken pre aortic occlusion and post reperfusion. Post reperfusion, mean (S.E.) FXR mRNA levels increased 3.41+/-1.07 fold (p
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".