Elevated C-reactive protein levels in osteoarthritis are associated with local joint inflammation
Bibliographic record
Abstract
Patients with idiopathic OA undergoing either total hip or knee arthroplasty or knee arthroscopic debridement were identified. Synovial membrane inflammation was graded intraoperatively and by histologic examination of samples obtained from standardized locations. Synovial fluid IL-6 levels and plasma CRP levels were measured using a high-sensitivity ELISA. Twelve patients with early OA and 37 patients with end-stage OA were identified. These OA patients were dichotomized into two groups: high CRP (CRP level > 3 μg/ml) and low CRP (CRP < 3 μg/ml). The high CRP group demonstrated elevated synovial fluid IL-6 levels ( P < 0.001) as well as increased intraoperative and histologic synovitis scores ( P = 0.045 and P = 0.03, respectively) compared with the low CRP group. There was a highly statistically significant correlation between synovial fluid IL-6 levels and systemic CRP levels (rho = 0.66, P < 0.001). We have demonstrated an association between a marker of systemic inflammation and local synovial inflammation in patients with OA. The more aggressive disease seen in OA patients with elevated CRP levels may be mechanistically linked to a more inflammatory synovial response in the diseased joint.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".